Friday’s headline event at Santa Anita is the $2 million Breeders’ Cup Distaff and will feature Untapable, the undisputed queen of the three-year-old fillies who goes up against older rivals after dominating her peers in all five starts this season.

The Steve Asmussen-trained Untapable won her first four starts of the year, including the Churchill Downs’ Kentucky Oaks in May and Belmont’s Mother Goose in June, by 31 lengths, but then was a disappointing fifth as the favorite when she took on the colts in the Haskell at Monmouth Park in July won by Bayern.

Untapable rebounded in Parx Racing’s Cotillion Stakes on September 20 and will put her 7-for-10 career record on the line when she tests older fillies and mares for the first time in the Distaff.

Untapable drew post 10 and was installed as 5-2 favorite.

Close Hatches was the undisputed divisional leader off a 4-for-4 record this year for trainer Bill Mott, but will need to rebound from a disappointing fourth at 1-5 in Keeneland’s Juddmonte Spinster Stakes on October 5.

The 4-year-old daughter of First Defence, who was second to Beholder in last year’s Distaff, won Oaklawn Park’s Apple Blossom in April, the Phipps and Saratoga’s Personal Ensign in August to take charge of the division.

Close Hatches is 9-for-13 for Mott, who has won the race an unprecedented five times.

Close Hatches breaks from post position in a field of 11 as the 3-1 second choice.

Belle Gallantey, who won Belmont’s Beldame Stakes for Rudy Rodriguez; Don’t Tell Sophia, who upset Close Hatches in the Spinster; Iotapa, who won the Vanity in June and Clement Hirsch at Del Mar in August, and was third in the Zenyatta for John Sadler; and Ria Antonia, second in the Spinster, are other leading contenders.

The $3 million Longines Breeders’ Cup Turf and $2 million Breeders’ Cup Filly & Mare Turf are shaping up as deep and wide open affairs.

The Turf over 1½ miles is led by Prix de l’Arc de Triomphe runner-up Flintshire, trained by Andre Fabre at 7-2.

The 4-year-old son of Dansili will be making only his fifth start this season after a major score last year in the Grand Prix de Paris.

Main Sequence appears to be the top American contender and has done little wrong in winning all three US starts for trainer Graham Motion in Monmouth Park’s United Nations in July, Saratoga’s Sword Dancer in August and Belmont Park’s Joe Hirsch Turf Classic on September 27.

The 5-year-old son of Aldebaran is 7-for-17 lifetime in a career that started in Europe.

Coolmore’s defending BC Turf champion Magician will also attract support for Aidan O’Brien.

The 4-year-old son of Galileo, has won just once this year, but has been second in three major races, two in Europe and the Arlington Million in Chicago.

Europe sends other formidable foes in Brown Panther, winner of the Irish St. Leger on September 14, and Telescope, Sir Michael Stoute’s Hardwicke Stakes winner at Royal Ascot and third in the Juddmonte International at York.

Other US contenders are Big John B, who won the Del Mar Handicap in August; Hardest Core, who took the Arlington Million on August 16 for trainer Eddie Graham; Imagining for trainer Shug McGaughey and Twilight Eclipse for trainer Tom Albertrani.

Wise Dan’s defection from the $2 million Breeders’ Cup Mile has opened up the race with an overflow field of 16 horses.

Al Shaqab Racing’s Toronado, who won the G1 Queen Anne Stakes at Royal Ascot for trainer Richard Hannon, leads a strong European challenge in the race as the 5-2 favorite.

The 4-year-old son of two-time Breeders’ Cup Turf winner High Chaparral lost the Prix de Moulin de Longchamp by a head in his most recent start on September 14.

Other top European raiders in the race are Qatar Racing’s Trade Storm, who won the Woodbine Mile on September 14 for David Simcock and Anodin, a full-brother to three-time Mile winner Goldikova who was second in the G1 Jacques le Marois at Deauville in August for Freddy Head and third to Toronado in the Queen Anne.

Leading American contenders in the race are Obviously, who won the Shoemaker Mile at Santa Anita in June and Tom’s Tribute, who won Del Mar’s Eddie Read Stakes and Del Mar Mile this summer for Jim Cassidy.