South Sydney coach Jason Demetriou says he's sick of his NRL team losing to Melbourne as they look to end the Storm's dominance in Sydney on Saturday night.

Coach Jason Demetriou has urged his troops to do "whatever it takes" to end Melbourne's dominance over South Sydney in their NRL clash on Saturday night.

Ahead of their Accor Stadium meeting, the Rabbitohs are looking to break a win drought against the Storm that dates back seven games to 2018.

South Sydney have only managed two victories against Melbourne in the last decade.

Demetriou was blunt when asked what his team needed to do to trump the visitors.

"Whatever it takes," the coach said.

"I'm over it to be honest, I'm over giving them two points every time we play them.

"We've got to go out and do whatever it takes."

Pipped by a Ryan Papenhuyzen golden-point field goal in round two at AAMI Park, this game appears to be Souths' best chance of a breakthrough win.

Injured Papenhuyzen is out for the season and Melbourne have lost three straight while the Rabbitohs have won their last three which has coincided with Latrell Mitchell's comeback from a long-term hamstring injury.

Demetriou lauded the impact of the fullback, who dominated their last-round victory over Canterbury.

"Latrell is under no illusion about the impact he can have on a game and he's learning what he needs to do off the field to give us 80 minutes every week," he said.

"When he does that he's a competitor and that's his best attribute ... he wants to win badly.

"He's enjoying being a leader, he's a guy who likes to stand in front of the boys and say come with me."

Melbourne coach Craig Bellamy said Mitchell had made a "massive difference" to Souths since his return and they would do their best to contain him.

"His athletic ability and skill as well, it's quite unique," Bellamy said of the 25-year-old.

"He's obviously a dangerous player and there's a couple of things we'll need to do well to try and slow down his effectiveness.

"You know at some stage he's going to be really hard to handle and hopefully that doesn't happen too often."

While the Storm have dropped their past three, including a 20-16 loss to Canberra last round, Bellamy felt they were on their way back up, with their defence improving.

"The Raiders scored three tries and two of them were on fifth tackles and the other an intercept so I think that was a step forward and we will keep working on our combinations in attack and defence," he said.

"Training has been better as well and hopefully we can continue with that sort of energy in the game, that sort of effort and start building our form back up."