Matt Ebden has lost the Wimbledon mixed doubles final with Samantha Stosur but gets another chance in the men's doubles decider on Saturday.

Tennis brave-heart Matt Ebden has fallen short in his quest for a Wimbledon title on a bittersweet afternoon for the West Australian at the All England Club.

Ebden and veteran Australian great Samantha Stosur lost to the second-seeded British-American pair of Neal Skupski and Desirae Krawczyk 6-4 6-3 in the mixed doubles final.

Skupski and Desirae Krawczyk are the first team to clinch back-to-back Wimbledon mixed doubles titles in a quarter of a century.

But Ebden gets a second chance when he teams up with Sydneysider Max Purcell in the men's doubles decider after staging an incredible fightback earlier on Thursday.

Ebden and Purcell stared down five match points in a pulsating third set before recovering to stun top seeds Rajeev Ram, of the US, and Brit Joe Salisbury 3-6 6-7 (1-7) 7-6 (11-9) 6-4 6-2 in a four-hour thriller.

The 34-year-old Ebden had every reason for feeling exhausted for the mixed final after he and Purcell recovered from the brink to become the first all-Australian combination since the legendary Woodies - Mark Woodforde and Todd Woodbridge - won the last of their six titles in 2000 to make the Wimbledon men's doubles decider.

Runners-up to Nick Kyrgios and Thanasi Kokkinakis in the Australian Open doubles final in January, Ebden and Purcell will play Croatian second seeds Nikola Metkic and Mate Pavic for the trophy on Saturday.